MultiMed Engineers – … go beyond

The IMPROVE Project presented at the IDE 2026 conference

19 September 2026

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On 10 and 11 September 2026, MultiMed Engineers, jointly with UPM and Dedalus, attended the IDE 2026 Conference (Ninth Edition) in Specchiolla (Brindisi, Italy), seizing the opportunity to present the objectives, approach and activities of the IMPROVE project, and how it leverages Patient Reported Outcome Measures (PROMs), Patient Reported Experience Measures (PREMs) and Patient Preference Information (PPI) in support of Value-Based Healthcare. The project has been presented on Thursday 10th, 2026 in the session dedicated to Digital Health, while its exploitation potential has been discussed in a restricted session on Friday 11th, dedicated to the prospects of Digital Health in the era of the European Health Data Space regulation and Generative AI.

Biomedical Applications Featured

Bulding a Community of Interest: discussing the IDEA4RC Ecosystem for Federated Rare Cancer Research with potential users

14 July 2026

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It was within this framework that, on 28 May 2026, MultiMed Engineers, together with the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan—the project’s coordinating institution—and the Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari, organised the workshop “IDEA4RC: An Intelligent Data Ecosystem for Rare Cancers. Opportunities and Challenges when Deploying a Regulatory-Compliant System for Multi-Centre Secondary Use of Health Data.”

The event was hosted by the Unit of Maxillofacial Surgery, at the Policlinico di Bari.

A perspective on using LLMs in digital health

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MultiMed Engineers explored how Large Language Models (LLMs) could be used to revisit and extend digital health functions investigated in BD4QoL and other projects. A multi-agent proof of concept was developed to experiment with LLM-based behaviour interpretation, affective assessment, anamnesis extraction, health-promotion content selection, symptom support and risk assessment. The work also investigates how natural-language prompts can make system specifications more directly understandable and discussable with healthcare professionals.

Assessing the operational costs of the IDEA4RC data ecosystem

MultiMed Engineers developed an operational cost assessment of the IDEA4RC federated data ecosystem, analysing the main platform components and their contribution to onboarding and recurring maintenance costs. The resulting framework provides a reference basis for planning the economic sustainability of participating Centres of Excellence and for assessing how costs may evolve as the network expands.

HTA of the BD4QoL digital follow-up platform

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MultiMed Engineers conducted the HTA study of the BD4QoL digital platform for Head and Neck Cancer survivors, using decision-analytic modelling. The analysis indicates that a five-year BD4QoL-supported follow-up can be cost-effective in preserving health-related quality of life. Additional scenarios explored predictor-guided interventions and the potential societal value of supporting survivors’ return to work.

Investigating AI modelling for predicting healthcare expenditure based on RWD

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MultiMed Engineers assessed the potential of the GATEKEEPER AI Framework in analysing real world datasets (RWD) available at AReSS Puglia, that include information on healthcare expenditure related to multimorbid chronic patients.

Assessment of an e‑coaching intervention for active and healthy ageing in the Puglia Region

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MultiMed Engineers conducted a series of analyses aimed at assessing the results of an e‑coaching program for active and healthy ageing directed to senior citizens in the Puglia Region, conducted in the frame of the GATEKEEPER Project.

Towards a digital human “behaviorome”

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MultiMed Engineers carried out research activities aimed to investigate the application of Data Analytics technology to the capture, analysis and interpretation of human behavior as a determinant of health. The expectation is that such effort would conduct to the definition of a digital human behaviorome that could greatly improve clinical research, by providing more informative features on people health conditions, linked to a modifiable determinant that can be used for improving health policies.

HTA for oncology prognostic models

Cattura2 MultiMed Engineers further applied its expertise in conducting HTA studies with the MAFEIP Tool, addressing the oncology domain. The health and economic effects of using the BD2Decide prognostic models in comparison with usual TNM staging, have been evaluated on the basis of the Project’s dataset, which includes several hundreds of Head & Neck Cancer cases. Four treatment escalation and de-escalation scenarios have been analysed.

HTA shows City4Age approach as viable

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MultiMed Engineers conducted a Health Technology Assessment for evaluating the frailty prevention scheme based on the City4Age Project’s early detection system. The results show that City4Age dominates the current standard of care from the Healthcare point of view, and exhibits a very cost-effective ICER of 3,380 €/QALY from the Societal perspective, allowing to conclude that the City4Age approach is viable.

Detecting frailty through smart-city datasets

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Thanks to the availablity of experimental datasets from the City4Age Athens Pilot, MultiMed Engineers investigated how Machine Learning algorithms can be leveraged to early detect frailty onset in aging citizens, living in smart-cities.

Chat-bot development

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MultiMed Engineers is experimenting the application of chat-bot technology to several business cases, including a NLP-based query language for a CRM database, and a conversational application to support a business-to-business “classifieds” system.

City4Age frailty and MCI risk model

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MultiMed Engineers, with the support of Università di Pavia (Department of Internal Medicine and Therapeutics), has drafted the first version of the City4Age frailty and MCI risk model. This document, which is a public deliverable of the City4Age Project (D2.1), presents the selection of geriatrics indicators that are currently being used to elaborate the behavioural markers for MCI and frailty, envisaged by the Project.

Download the executive summary…

Biomedical Applications

IDEA4RC Newsletter #14

31 August 2026

As IDEA4RC reaches the end of its four-year journey, we spoke with project coordinator Annalisa Trama, head of the Epidemiology Unit at the National Cancer Institute of Milan and responsible for the EURACAN registry, the registry of the European Reference Network for rare adult solid cancers…

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Digital Technologies

Reasoning with LLMs and formal reasoning are most effectively leveraged in combination.

18 August 2026

A marriage of formal methods and LLMs seeks to harness the strengths of both.…

Source: Communications of the ACM, Vol. 69, No. 3, Formal Reasoning Meets LLMs: Toward AI for Mathematics and Verification

Biomedical Applications

IDEA4RC Newsletter #13

7 August 2026

In this newsletter, we update you about the final plenary meeting of IDEA4RC, held in Madrid on June 24 and 25. We also share the highlights of the workshop IDEA4RC organised at the Ministry for Digitalization of the Community of Madrid to showcase the project’s solutions and discuss its impact. Finally, we look ahead to the “5 years EU Cancer Mission: Stronger Through Connection” conference, where IDEA4RC will be represented as the mission marks its fifth anniversary…

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Biomedical Applications

Welcome to the ENKORE 2nd Newsletter

22 July 2026

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Second edition with the latest updates from across the project:

Co-developing Circular Solutions at Frisius MC

Patient Perspectives in Healthcare

ENKORE presents its project poster at The MedTech Forum 2026

Shaping the future of circular healthcare at the DICE policy event

Biomedical Applications

IDEA4RC Newsletter #12

18 June 2026

In this newsletter, we are excited to share IDEA4RC’s participation in Vitalis 2025, the leading eHealth event in Scandinavia, which was held in Gothenburg from May 19 to 22.…

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